Bone Abstracts

Objective: Osteogenesis imperfecta (OI) which is a heterogenic group of diseases presenting with bone fragility, skeletal deformations and limited mobility may confer a risk of several non-skeletal health issues and is associated with adaptational social problems. The aim of the qualitative descriptive study was to determine the most important areas (problems?) related to social functioning, familial environment, hospital amenities and social needs in children with OI.<p c...

Juvenile dermatomyositis (JDM) is a severe connective-tissue disease of unknown etiology characterized by inflammatory process affecting muscles and skin, with subsequent presentation in the joints, esophagus, lungs, and the cardiovascular system. Clinical presentation also includes deposition of calcium in the skin (calcinosis cutis) which is typically seen in the juvenile DM, contrary to the adult form. The pathogenesis of JDM-related calcinosis remains unclear wher...

Background: Hypophosphatasia (HPP) is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific alkaline phosphatase gene (TNSALP), leading to low alkaline phosphatase (ALP) activity. At least 6 clinical forms of HPP have been reported. Certain benign or asymptomatic presentations of HPP in older children may remain undiagnosed, in contrast to severe perinatal and infantile types. The underlying reason of this diagnostic inconsisten...

Background: Chronic rheumatic conditions including juvenile idiopathic arthritis (JIA) lead to the deterioration of bone mineral metabolism and confers risk of fragility fractures. Although contemporary medical therapies have limited skeletal complications in JIA, some rare cases of severe osteoporosis are still reported in these patients. Systemic glucocorticoid (GCS), long-term inflammation, and disease-related immobility are responsible to skeletal damage in JIA.<p clas...

Objective: Associations between childhood obesity and disturbed bone metabolism have been extensively studied. Both RANK/RANKL/OPG and adipocytokines are involved in bone metabolism in obese individuals although published data remain inconsistent. Some reports show evidence of protective role of adiposity in the maintenance of skeletal mass, whereas others fail to support this evidence or even demonstrate an increased fragility. The aim of the study was to assess bone metaboli...

Objective: Insuficient vitamin D supply defined as serum hydroxyvitamin D (25OHD) <20 ng/ml is considered as one of possibile cardiovascular risk factors among adults with hypertension. Furthermore, some data also suggest an independent association between vitamin D deficits and hypertension and obesity during growth. The aim of the study was to assess vitamin D status in children and adolescents with hypertension.Methods: The cross sectional study w...

Objective: Assessment of bone mineral density in children completing therapy for lymphoma.Methods: Thirty-five children treated for childhood Hodgkin and non-Hodgkin lymphoma at the Department of Pediatric Hematology and Oncology of Medical University of Bialystok in Poland were included. Patients were scanned with DXA at two time points: 1st – up to 5 years and 2nd – above 5 years after the completion of the treatment. Bone mineral density (to...

Objective: Assessment of low bone mass in children with acute lymphoblastic leukemia.Methods: A total of 141 patients (83 boys and 57 girls) treated for acute lymphoblastic leukemia at the Department of Pediatric Hematology and Oncology of Medical University of Bialystok in Poland were assessed for low bone mineral density. Depending on age of diagnosis three clinical groups were analyzed: i) up to 5 years old, ii) from 6 to 12 years old, and iii) from 1...

Vitamin D deficiency has been reported in adult patients with autoimmune diseases including rheumatoid arthritis, however, the data in patients with juvenile idiopathic arthritis (JIA) are inconsistent. The aim of the study was to assess serum 25-hydroxyvitamin D (25(OH) D in children and adolescents with JIA, and to determine potential risk factors for vitamin D deficiency.In this cross-sectional study, we evaluated 189 patients with JIA (113 girls, 76 ...

Introduction: Serum 25(OH)D concentrations for optimal bone metabolism in children is unknown. Only few data exist describing the effects of increasing serum 25(OH)D on bone metabolism markers.Aim: The aim of the study was to explore the association between serum 25(OH)D and bone metabolism markers in children.Patients and methods: Serum levels of bone formation (OC, P1NP) and bone resorption (CTx) markers (Cobas e411, Roche Diagno...